Therapeutic JQ-1 administration did not affect the heart rates of the sham and MI mice (Fig. 4B) and had beneficial effects in attenuating cardiac injury and dysfunction in MI mice, as demonstrated by higher LVEF and LVFS values, lower heart weight to tibia length ratios, reduced infarct areas, less interstitial fibrosis, and decreased mRNA levels of cardiac stress genes including Nppa, Nppb, and Myh7 (Fig. 4C–I). Here, NPPA is linked to myocardial infarction.