Consistent with our hypothesis, ILF3 knockdown decreased cystine uptake, GSH synthesis, and the NADP + /NADPH ratio in CRC cells (Fig. 4H–J), while other ferroptosis-related factors, including ACSL4, FTH1, and TFRC, remained unaffected (Fig. S3C). The gene discussed is ILF3; the disease is colorectal carcinoma.