On the contrary, when MH fusion gene was knocked down in Kasumi-7 cells and leukemia cell death was induced as previously described,10 our re-analysis of relevant data found PI3K/AKT signaling pathway, HDAC targets, MAPK signaling pathway, and B cell activation pathways were significantly down-regulated (Fig. 3f). The gene discussed is PIK3CD; the disease is leukemia.