However, kinases like glycogen synthase kinase-3β (GSK-3β) typically phosphorylate Snail1, Snail2, and Twist, priming them for recognition by E3 ligases and subsequent degradation [44].In addition to transcription proteins, phosphorylation also stabilizes cytoskeletal proteins, affecting EMT in CRC. The gene discussed is SNAI2; the disease is colorectal carcinoma.