C5aR1 mRNA levels were significantly increased in severe hypoxia (<0.1% O2) but not milder levels (1% O2) in colorectal and glioblastoma cancer cells (Fig. 1D, E, and Supplementary Fig. 1B-D, showing similar effect in ovarian and prostate cancer cells). The gene discussed is C5AR1; the disease is Familial prostate cancer.