In recent ten years, more and more studies have shown that BEX family proteins participate in multiple molecular signaling pathways in cancers, liver diseases, heart diseases et al. These evidences hint that BEX family proteins maybe potential therapeutic targets for multiple diseases.<h4>Aim of review</h4>In this review, we systematically summarize the research progress on the role of BEX family proteins in patients with various cancers. Here, BEX3 is linked to liver disorder.