Circulating NrCAM was reduced in 41 participants with preterm preeclampsia (median = 6.7 × 103 pg/mL; IQR, 3.9–9.2 × 103 pg/mL), compared to 20 gestation matched controls (median = 1.0 × 104 pg/mL; IQR, 8.4 × 103 pg/mL–1.5 × 104 pg/mL, p = 0.0003, Fig. 3b). Here, NRCAM is linked to preeclampsia.