NRCAM and preeclampsia: In the PROVE cohort, circulating NrCAM was reduced in 27 participants with severe preeclampsia (median = 4.2 × 103 pg/mL; IQR, 2.7 × 103 pg/mL–7.7 × 103 pg/mL), compared to 15 controls (median = 6.1 × 103 pg/mL; IQR, 5.4 × 103 pg/mL–1.4 × 104 pg/mL, p = 0.03, Fig. 2e).