These in total 12 genes contain 8 oncogenes as defined by the OncoKB database (PDGFRA, E2F3, EGFR,CDK6,MYC, CCND1, IGF1R, and CCNE1) but also 4 genes with a lesser known role in cancer (SLBP,WNK1, TGIF1, and TUBB4B), which suggests that these genes might be important in oncogenesis through low-amplitude copy number gain. The gene discussed is EGFR; the disease is cancer.