STAMBP and diabetic retinopathy: Suppression of innate immune-mediated inflammation by α-MSH appears mostly through MCR1 with MCR3.7,39,47 With MCR5 stimulation, α-MSH mediates the induction of suppressor APCs that counter-convert autoantigen-specific effector T cells into inducible T cells.8,48,49 Preserving retinal structure and cell survival needs MCR1, MCR4, and MCR5 stimulation during inflammation and diabetic retinopathy.7,50–55 Our results demonstrate that treatment with the RCI gel suppressed EAU through general suppression of immune cell activity without Treg cell development while protecting the retina.