Therapeutic application of α-MSH into EAU mice results in suppression of uveitis, preservation of retinal structure, and induction of splenic suppressor APCs and autoantigen-specific Treg cells.30,32,44–46 This response is absent of glucocorticoid stimulation since the native neuropeptide α-MSH binds to the other four MCRs but not MCR2. This evidence concerns the gene STAMBP and uveitis.