The suppression of EAU with α-MSH or MCR-agonists results in the establishment of ocular immune privilege and immune tolerance to ocular autoantigens, providing a potentially long-term resistance to the recurrence of uveitis.7,12 While the application of the RCI-gel suppresses EAU, whether this is associated with the reestablishment of ocular immune privilege and an immunosuppressive microenvironment will have to be studied. This evidence concerns the gene NR3C2 and uveitis.