The study has identified 6 oxidative stress-related genes (VDAC1, HSPA8, HSPA9, SOD1, TXN, and SNCA) that was closely correlated with the onset of sepsis-induced ALI through several machine learning algorithms VDAC1 is located on the outer membrane of mitochondria and serves as a crucial channel that facilitates the transport of metabolites and ions in and out of these organelles [35]. Here, HSPA8 is linked to Sepsis.