MYC and small cell lung carcinoma: Our choice of MYC to serve as an oncogenic driver in hESC-derived PNECs was based on both the frequent finding of high levels of MYC RNA in human SCLC and the use of Myc overexpression strategies to generate aggressive mouse models of SCLC (Ireland et al., 2020; Mollaoglu et al., 2017; Huijbers et al., 2014; Ciampricotti et al., 2021; Kim et al., 2016).