NEUROD1 and small cell lung carcinoma: We conducted differential gene expression to further characterize the NEUROD1-high (abbreviated ‘NE-variant’) and ASCL1-high (abbreviated ‘NE’) clusters observed with RPM cells (from cell lines and tumors) and found that the NE-variant cluster was associated with increased expression of genes highly expressed in variant SCLC (NEUROD1, SCG3, IGFBPL1, SSTR2, and MYC) (Figure 4—figure supplement 1D, Supplementary file 1).