F2RL1 and breast cancer: To specifically investigate FXa-PAR2 signaling–dependent alterations of tumor infiltrating macrophage and DC phenotypes, we compared single cell RNA sequencing (scRNA-seq) profiles of CD11c-selected cells from the TME of the spontaneous breast cancer model PyMT, developing in FXa signaling–resistant PAR2G37I and signaling-competent PAR2WT mice (26), later referred to as PyMT-PAR2G37I or PyMT-PAR2WT.