When comparing DM CLL cells and Mdr MT CLL cells, almost all the cellular pathways were highly enriched except the RNA metabolism pathway (Figure 3B and Supplemental Figure 3B), highlighting that Sf3b1-K700E and Mdr deletion synergistically contribute to the progression of CLL via the regulation of mTORC1 signaling, MYC activation, and cell cycle. This evidence concerns the gene SF3B1 and B-cell chronic lymphocytic leukemia.