AKT1 and B-cell chronic lymphocytic leukemia: Furthermore, we verified that DM CLL cells had a stronger impact on MYC expression and mTORC1 pathway activation compared with Mdr MT CLL cells, as demonstrated by increased levels of MYC protein and phosphorylated (p-) mTORC1 and its direct and indirect targets, including p-4E-BP1 T37/46, p-S6-S235/236, and p-Akt-T308 (Figure 3F), corroborating with gene expression–based pathway enrichment (Figure 3B).