In total, 1,029 and 376 spliced genes were identified to be associated with DM CLL and Sf3b1 mutation, respectively; 117 spliced genes overlapped between the 2 groups (Supplemental Table 3), with 7 genes having direct interaction with MYC and mTORC1 protein based on the STRING database (Nfatc1, Atf2, Hdac6, Pbrm1, Ptprc, Tbl1xr1, Hdac10) (Figure 4C). The gene discussed is TBL1XR1; the disease is B-cell chronic lymphocytic leukemia.