NUAK1 and metabolic dysfunction-associated steatohepatitis: In another article of Hepatology Communication, Sheng et al4 delineated the mechanism of inflammation in MASH and demonstrated the significant upregulation of AMPK-related kinase 5 [also known as NUAK family SNF1-like kinase 1 (NUAK1)] in liver tissues of MASH patients and mice fed with a high-fat diet (HFD).