MTARC1 and metabolic dysfunction-associated steatohepatitis: By using N-acetylgalactosamine (GalNAc)-conjugated siRNA, Guo et al6 demonstrated that liver-specific knockdown of mitochondrial amidoxime–reducing component 1 (MTARC1), which was specifically located on the mitochondrial outer membrane for reducing nitrite or N-hydroxylated prodrugs in hepatocytes, protected against diet-induced MASH in multiple MASLD/MASH mouse models (ob/ob, AMLN diet, CDAHFD).6