Conversely, NPTX2 levels were negatively correlated with the duration of diabetes (r ═ −0.219, P ═ 0.038), patient age (r ═ −0.289, P ═ 0.006), nephropathy (r ═ −0.253, P ═ 0.016), retinopathy (r ═ −0.281, P ═ 0.007), polypharmacy (r ═ −0.279, P ═ 0.008), CHF (r ═ −0.216, P ═ 0.041), and AF (r ═ −0.283, P ═ 0.007). This evidence concerns the gene NPTX2 and diabetes mellitus.