The AI model classified more patient samples as HER2-ultra-low as compared to conventional microscopy and digital visual evaluation, which can be explained by the number of tumor cells with membranous staining near the cutoff value of 10% (for HER2-low versus HER2-ultra-low status) or the cutoff value of 1% (for HER2-ultra-low versus HER2-null status). This evidence concerns the gene ERBB2 and neoplasm.