Notably,both the 02_DCH_A-P1 and 02_DCH_A-P2 nanogels exhibited over threeand 16 times higher efficacy, respectively, in CP-resistant A2780cells compared to the parental A2780 cell line, further strengtheningthe effect observed in free PhPt, which was 1.3 times more effectivein cisplatin-resistant A2780/CP cells than in the parental A2780 cells.Our findings thus demonstrate that binding to nanogels enhances thetherapeutic potency of the PhPt and significantly increases its cell-killingactivity in cisplatin-resistant ovarian cancer cells. Here, CP is linked to ovarian cancer.