As to BBB-compliant agents, dibenzothiophene bis-GHhit 4 interacts with a bulge region in the pre-mRNA sequenceof tau, actingas a pre mRNA splicing modifier and rebalancingthe 3R/4R tau isoform ratio, typical in tauopathies,by exclusion of exon 10 at low micromolar concentrations. This evidence concerns the gene MAPT and tauopathy.