The coactivator p300, a member of the HAT family, regulates transcription factors like nuclear factor kappa B subunit 1 (NF‐κB) and carbohydrate‐responsive element‐binding protein (ChREBP), which are central to lipid synthesis and inflammation in hepatic steatosis and HCC.80 The gene discussed is MLXIPL; the disease is hepatocellular carcinoma.