Gene modifiers like specific single nucleotide polymorphisms (SNPs), such as patatin‐like phospholipase domain‐containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2), impact MASLD severity, increasing the risk of complications like HCC.22 This evidence concerns the gene TM6SF2 and hepatocellular carcinoma.