Specifically, we demonstrated that acetate produced by F. rodentium increases CD8+ T-cell immunity and modulates PDPN/CLEC-2/PI3K/AKT/mTOR signaling by downregulating PDPN expression on CD8+ T cells and CLEC-2 expression on tumor cells, resulting in the inhibition of CRC. The gene discussed is CD8A; the disease is neoplasm.