ADAR and viral infectious disease: Since the loss of one Adar allele is enough to tilt the immune system in RdRptg mice to a highly pathogenic autoinflammatory outcome, it can be speculated that, in some natural circumstances, viral infections—and the inflammatory signaling cascades they induce—have roles in triggering human autoinflammatory diseases, particularly when they also disturb the finely regulated, complex equilibrium of A-to-I editing.