TRIM21 and Sjogren syndrome: 2012 American College of Rheumatology classification criteria for Sjögren’s syndrome (at least 2 out of 3 of the following objective tests):•Positive serum anti-SSA (Ro) and/or anti-SSB (La) or positive RF and ANA ≥ 1:320•Ocular staining score ≥ 3•Labial salivary gland with focal lymphocytic sialadenitis and focus score of ≥1 foci/4 mm2