In addition to global immune suppressors such as steroids, cyclosporin and tacrolimus, mechanism‐based anti‐inflammatory biologics, including IL‐13, IL‐31 antibodies, small molecules, JAK kinase inhibitors, PDE inhibitors and aryl hydrocarbon receptor (Ahr) modulators, have all have been developed to treat AD. The gene discussed is IL13; the disease is Alzheimer disease.