Additionally, compared with normal mice, tumor-bearing mice presented substantially higher levels of VEGFA (22.3 versus 16.4 pg/mL), VEGFC (40.3 versus 31.3 pg/mL), and VEGFD (43.5 versus 33.4 pg/mL) in the peripheral blood (Figure 2F), indicating that these factors were secreted into the TDLN. This evidence concerns the gene VEGFD and neoplasm.