A prominent feature of MPI-CDG is hepatic fibrosis, which causes elevated liver enzymes and decreased synthesis of certain coagulation factors (serpin family C member 1, also known as ATIII; protein C, inactivator of coagulation factors Va and VIIIa) and growth hormones (insulin like growth factor 1, IGF-1). The gene discussed is GH1; the disease is congenital disorder of glycosylation.