BCR and cancer: Factors, such as tumor cell proliferation, B‐cell receptor (BCR) richness (i.e., the diversity of unique BCR clonotypes), TGF‐beta response, macrophage abundance, leukocyte and stromal fractions, lymphocyte infiltration, and T‐cell receptor (TCR) richness all play crucial roles in either promoting or preventing cancer development within the TME [33].