DUSP6 encodes a dual specificity protein phosphatase subfamily member that has wide‐ranging effects on cell behaviour by acting on extracellular signal‐regulated kinases (ERK) proteins in the mitogen‐activated protein (MAP) kinase superfamily; mutations in DUSP have been linked to hypogonadotropic hypogonadism.58 This evidence concerns the gene DUSP6 and hypogonadotropic hypogonadism.