APMAP is widely distributed in mammals and has been demonstrated to be associated with various diseases, including gestational diabetes mellitus, polycystic ovary syndrome, primary Sjogren’s syndrome, demyelinating disease and Alzheimer’s disease (Ilhan et al., 2008; Gerber et al., 2019; Haley et al., 2020). The gene discussed is APMAP; the disease is early-onset autosomal dominant Alzheimer disease.