Among them, harmine has been reported to inhibit MAO, AChE, and dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), thereby exerting various pharmacological effects, including antitumor, antioxidant, anti-inflammatory, anti-Alzheimer’s disease and antidepressant effects (He et al., 2015; Jiang et al., 2019; Tarpley et al., 2021). The gene discussed is DYRK1A; the disease is early-onset autosomal dominant Alzheimer disease.