FN1 and obesity due to melanocortin 4 receptor deficiency: We next quantified mRNA levels of α-SMA, Collagen I, and Fibronectin in pancreatic tissue, as a key response to chronic pancreatic damage, which also plays a significant role in the progression of pancreatic diseases, including pancreatitis, pancreatic cancer, and metabolic disorders such as obesity and diabetes (Li X. et al., 2021).