Our data clearly showed the importance of immune modulation of IL-6R on trNK cells in remodeling pancreatic tissue affected by liver injury insults, highlighting the liver-pancreas axis as a target therapy to prevent pancreatic damage, particularly β-islet cells dysfunction or loss, pancreatic fibrosis, and therefore minimize the risk of diabetes mellitus and other associated metabolic syndromes. This evidence concerns the gene IL6R and diabetes mellitus.