To assess the impact of liver disease on the extent of pancreatic injury in Ob/ObHFD mice, we first measured the pancreas-to-mouse weight ratio and the expression of the regenerating islet-derived genes Reg1 and Reg3, which serve as sensitive markers of pancreatic injury and attempted repair (Girón-González and Salto, 2021). Here, ZC3H12A is linked to liver disorder.