Cancer cells display significant lipid metabolism alterations, including increased fatty acid oxidation regulated by carnitine palmitoyltransferase 1B (CPT1B) and activation of the JAK/STAT3-CPT1B-FAO axis, which reinforces stemness and chemoresistance—a metabolic shift particularly pronounced in cisplatin-resistant ovarian cancer (Wang et al., 2018; Yoshida, 2015). The gene discussed is CPT1B; the disease is cancer.