Metabolomic profiling identified the sphingosine-1-phosphate receptor 1 (S1PR1)-STAT3-CerS3 signaling axis in endothelial cells as a driver of HCC angiogenesis through ceramide metabolism modulation, with S1PR1 inhibition showing synergistic effects when combined with Lenvatinib (Wang et al., 2022). The gene discussed is S1PR1; the disease is hepatocellular carcinoma.