POSTN and cholangiocarcinoma: The cholangiocarcinoma study integrated analysis of 85 PANoptosis-related genes to uncover POSTN+ CAFs as key resistance orchestrators spatially linked to immunosuppressive TAMs and PD-L1/2, while developing the clinically actionable PANRS model (POSTN/SFN/MYOF/HOGA1/PECR) (Yu et al., 2025).