The multidrug resistance protein P-glycoprotein (P-gp), encoded by MDR1, actively exports chemotherapeutics; in ovarian cancer, exosomal miR-1246 amplifies P-gp function through the Cav1/P-gP/PRPS2 axis, reducing paclitaxel uptake and accelerating chemoresistance (Kanlikilicer et al., 2020). The gene discussed is PGP; the disease is ovarian carcinoma.