Higher sGFAP at V2 was strongly associated with more extensive longitudinal brain atrophy in patients with AQP4-IgG+NMOSD (β = −0.06 (−0.11, −0.002), p = 0.04), while no such association was observed in patients with MOGAD (β = −0.02 (−0.08, 0.05), p = 0.55, SESint = 0.2 (−0.3, 0.8), pint = 0.37, Figure 3(c)). The gene discussed is AQP4; the disease is Brain atrophy.