However, our report revealed only a decrease in SM(24:0), Cer(d18:1/18:1), Cer(d18:1/16:1) and Cer(d18:1/24:1)levels was explicitly shown in the hippocampal tissue of 7.5-month-old AD mice, whereas previous research reported a decline in SM levels only at 2 and 3 months old and no change at 7 months old (Zhang et al., 2020). Here, CBLN1 is linked to Alzheimer disease.