APP and Alzheimer disease: This is particularly evident in the imbalances of phospholipids observed in both serum and cerebrospinal fluid (CSF) of AD patients (Farooqui et al., 1988; Koal et al., 2015), as well as lipid disturbances noted in cortical and serum samples of APP/PS1 mice (Yao et al., 2009; Shen L. et al., 2017).