In PubMed, the search used was ("SGLT2 Inhibitor"[Mesh] OR "Sodium-Glucose Transporter 2 Inhibitors" OR "Empagliflozin" OR "Dapagliflozin" OR "Canagliflozin") AND ("Heart Failure with Preserved Ejection Fraction"[Mesh] OR "HFpEF" OR "Heart Failure, Diastolic" OR "Preserved Ejection Fraction") AND ("Placebo" OR "Standard Care" OR "Control Group"). The gene discussed is SLC5A2; the disease is heart failure.