For the Cochrane Library, the search string was ("SGLT2 Inhibitor" OR "Sodium-Glucose Cotransporter 2 Inhibitor" OR empagliflozin OR dapagliflozin OR canagliflozin) AND ("Heart Failure with Preserved Ejection Fraction" OR HFpEF OR "diastolic heart failure") AND ("Placebo" OR "Standard Care"). The gene discussed is SLC5A2; the disease is diastolic heart failure.