Although studies have investigated the role of systemic inflammatory biomarkers, such as RDW [23], neutrophil-to-lymphocyte ratio (NLR) [24, 25], RDW-to-platelet ratio (RPR) [26], glucose-to-lymphocyte ratio (GLR) [27], and C-reactive protein-to-albumin ratio (CRP/Alb) [28] in predicting ARDS prognosis, the ALBI score uniquely integrates hepatic and inflammatory profiles, offering a multidimensional assessment tool for ARDS prognosis. The gene discussed is CRP; the disease is acute respiratory distress syndrome.