These findings indicate that PLAC9, CHI3L1, SNORA48, and CCN2 were significantly upregulated in the spleen following infection, whereas C1QA, ADA, ND4L, MPEG1, LDHB, MARCO, C1QC, C1QB, and CLEC4F were significantly downregulated (Figures 3F). The gene discussed is CHI3L1; the disease is infection.