By contrast, studies with small sample sizes (<100) suggested that elevated DBC1 expression was correlated with poorer histologic grade (n = 2, RR = 2.123, 95%CI: [1.352-3.336], P = 0.001, I2 = 0.0) and increased tumor invasion (n = 2, RR = 2.661, 95%CI: [1.489-4.756], P = 0.001, I2 = 0.0). The gene discussed is CCAR2; the disease is neoplasm.