MAP2K1 and cardiofaciocutaneous syndrome 1: Among these, cardiofaciocutaneous syndrome (CFCS; OMIM #115150, #615278, #615279 and #615280) is a rare autosomal dominant disease that affects 1/800,000 newborns (1) and it is caused by mutations in BRAF, MAP2K1, MAP2K2, KRAS and YWHAZ genes (2).