Safety and Effectiveness Study of RWJ-445380 Cathepsin-S Inhibitor in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy, (n.d.)https://clinicaltrials.gov/study/NCT00425321?tab=history&a=12Study to Investigate the Safety, Tolerability, Absorption, Distribution, Metabolism, and Elimination of RWJ-445380 Administered to Patients With Plaque Psoriasis, (n.d.)https://clinicaltrials.gov/study/NCT00396422?tab=history&a=5. The gene discussed is CTSS; the disease is psoriasis.