Lactobacillus treatment can prevent the onset of arthritis in preclinical models, reduce arthritis scores in CIA rat and pro-inflammatory cytokines (such as IL-17, IL-1β, IL-6, and TNF-α), and increase the release of anti-inflammatory cytokines like IL-4 and IL-10 in bodily fluids (109). The gene discussed is TNF; the disease is Arthritis.