LYN and Fever: In systemic autoinflammation (such as LE and Ptpn6me - v/me - v mouse models), LYN deficiency or functional abnormalities (such as the pTyr508His mutation) lead to the over-activation of the NF - κB pathway, triggering severe systemic inflammatory responses (such as fever, chronic urticaria, and hypercytokinemia) (50).