Within sustained chronic activation and thus endothelial dysfunction (but also within acute activating conditions), the nuclear transcription factors NF-κB should be considered as key regulator of most cytokines and adhesion molecules induced in the endothelial cells (Guo et al., 2024; Hallahan et al., 1998; Poulos et al., 2016; Sonveaux et al., 2017). Here, NFKB1 is linked to endothelial dysfunction.