Moreover, the diffuse MIST1 expression and decreased α-1,4-linked N-acetylglucosamine (αGlcNAc) glycosylation of MUC6 are the obvious markers of gastric neoplasms with oxyntic gland differentiation, suggesting that decreased αGlcNAc glycosylation of MUC6 and diffuse positivity of MIST1 also play an important role in tumor origin [27]. This evidence concerns the gene MUC6 and gastric neoplasm.