DES and neoplasm: For a more accurate classification, some scholars suggest that the clinical ESD or endoscopic mucosal resection (EMR) resection be further performed depending on the biopsy-based diagnosis in the oxyntic gland-type tumor; if infiltration of the submucosal layer is observed, the recommended diagnosis is GA-FG [18], and we also suggested that desmin staining should be used to mark the muscularis mucosae to better identify if the tumor had invaded beyond the muscularis mucosae.