As is known, the RORB gene is associated with susceptibility to idiopathic generalized epilepsy-15 (EIG15; OMIM #618357), an autosomal dominant disease with possible incomplete penetrance which is characterized by the occurrence of different types of epileptic seizures within the first decade (Rudolf et al., 2016; Dong et al., 2021). Here, RORB is linked to Seizure.