In high-fat diet and letrozole-induced PCOS rats model, Liang et al (45) found that resveratrol administration significantly decreased FBG, FINS, and HOMA-IR levels, concomitant with downregulated insulin-like growth factor-1 (IGF-1) and upregulated IGF-1 receptor expression. This evidence concerns the gene IGF1 and polycystic ovary syndrome.