PRKCG is a member of the conventional protein kinase C (PKC) subfamily, requires Ca2+ for its activation, and is expressed only in the central nervous system. PRKCG functions initially in a deleterious fashion in response to ischemia, and later as a protective factor in the period of postischemic reperfusion (Chou and Messing, 2005). This evidence concerns the gene PRKCG and ischemia.