EDN1 and diabetes mellitus: Diabetes patients with medium ET‐1 levels and those with high ET‐1 levels were found to have a higher risk of MACE by multivariable regression analysis, with an adjusted HR of 2.082 (95% CI, 1.291–3.357, p < 0.001) and 2.134 (95% CI, 1.334–3.413, p < 0.001), respectively (Table 3).