Furthermore, diabetes patients with intermediate ET‐1 levels and those with high ET‐1 levels were found to have a higher risk of MACE with SHR of 1.961 (95% CI, 1.104–3.485, p = 0.022) and 2.192 (95% CI, 1.262–3.804, p = 0.005), respectively, which were consistent with Cox analysis. The gene discussed is EDN1; the disease is diabetes mellitus.