Continuous production of ET‐1 in the vasculature is essential for maintaining vascular tone [14] and blood pressure [15], thus playing a role in baseline vascular tension and the pathogenesis of several diseases such as hypertension [16, 17], CKD [18, 19], pulmonary arterial hypertension (PAH) [20, 21], and preeclampsia. The gene discussed is EDN1; the disease is hypertensive disorder.