CYP2E1 and metabolic dysfunction-associated steatotic liver disease: We found that, e.g. AIVIVE effectively replicated the expression pattern of Cyp2e1 (Cytochrome P450-2E1), a hepatic enzyme responsible for the biotransformation of substances like ethanol and upregulated in NAFLD (Leung and Nieto 2013; Abdelmegeed et al. 2017).