Ruff et al. identified a specific population of cortical γ-aminobutyric acid (GABA)ergic neurons with neuronal nitric oxide synthase and TACR1 in mice and humans, and TACR1 neurons are strong mediators of vasodilation, which is one cause of nausea [7], through feedforward excitatory pathways in the CNS [39]. The gene discussed is TACR1; the disease is Nausea.