GSDMD and neoplasm: For instance, when IR780, a photosensitizer was delivered via nanomicelles to CD320-overexpressing gastric cancer cells, upon near-infrared (NIR) light exposure mitochondrial ROS production increased, activating the NLRP3 inflammasome, caspase-1, and GSDMD, leading to pyroptosis and enhanced anti-tumor immunity [239].