They found out that co-culturing M2 macrophage-derived small EVs with BC tumor cells determined an increase in lncRNA LINC00470, myc, and DNA (cytosine-5)-methyltransferase 3 A (DNMT3A) expression levels and a downmodulation of miR-199a-3p, resulting in a higher proliferation rate and invasive ability of tumor cells. The gene discussed is MYC; the disease is neoplasm.