Liu J et al.; described the role of the lncRNA Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) in the promotion of angiogenesis in TNBC TME: in Jagged-1 (JAG1, ligand of NOTCH signaling pathway) overexpressing BC cells the release of small EVs is promoted and MALAT1 is transferred to endothelial cells, where it targets miR-140-5p [68]. Here, JAG1 is linked to breast cancer.