Liu Q.W. and colleagues described that BC-released small EVs can downregulate the expression of chemokine receptor CXCR4 and increase the levels of inflammatory cytokines IL-6 and IL-10 in myeloid cells, thus impairing T cell proliferation; MDSC expansion was further stimulated through the activation of STAT3 signaling pathway [61]. The gene discussed is STAT3; the disease is breast cancer.